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The microbial translocation through the disrupted tight junctions of GI cells promotes systemic inflammation and can alter the BBB or cause other direct CNS effects via the Vagus nerve

Once localized, it exerts potent organelle-specific protective effects, such as directly binding to the juxtamembrane loop domain of the mitochondrial calcium uniporter (MCU) to prevent rapid Ca 2+ overload, and modulating mitochondrial complex I via SIRT3-dependent mechanisms (Zhao et al., 2025

Although sex is a crucial biological variable, the limited representation of males with LC compared to females in our cohort prevented us from observing any significant differences